礞石涤痰汤对精神分裂症一氧化氮超氧化物歧化酶的影响及其临床疗效研究

Clinical Study of Mengshi Ditan Decoction Treatment Schizophrenis about Nitre Oxide(NO) and Superoxide Dismutase(SOC)

目的：探讨礞石涤痰汤治疗精神分裂症的临床疗效。方法：将96例精神分裂症患者随机分为两组,对照组用抗精神分裂症西药治疗,治疗组在西药治疗的基础上加服礞石涤痰汤,治疗6周评定疗效。用阳性与阴性症状量表（PANSS）、BPRS因子评分和副反应量表（TESS）,评定疗效和不良反应。治疗前后测一氧化氮（NO）和超氧化物歧化酶（SOD）。结果：中西药结合组显效率64.00%,对照组显效率43.48%（P〈0.01）,中西药结合组不良反应少于对照组（P〈0.05~0.01）。治疗后SOD增高,而NO则有所下降,两组间治疗后比较有显著差异（P〈0.05）,各组自身与治疗前比较,治疗组均有意义（P〈0.05）,对照组NO有意义（P〈0.05）,而SOD在治疗前后则无统计学意义（P〉0.05）。结论：中药礞石涤痰汤对精神分裂症有治疗作用。中西医结合治疗精神分裂症疗效优于单纯西药治疗,其毒副反应及疗程均优于单纯西药治疗。

Objective ：To study the therapeutic effect of Mengshi Ditan Decoction for Schizophrenia. Methods： Totalling 96 cases of schizophrenics were randomly divided into 2 groups. The control group was treated by westem medicine, while Mengshi Ditan Decoction was added in the treatment group. Positive and Negative Symptoms Scale （PANSS） , Brief Psychiatric Pating Scale（BPRS） and Treatment Emergent Symptom Scale （TESS） were used to identify the therapeutic and adverse effect after 6 weeks treatment. Before and after treatment plasma nitre oxide（NO） and superoxide dismutase （SOD） were measured. Results ：the excellence rate in treatment group was 64.00% ,while 43.48% in control group（ P 〈0.01）. The adverse effect in treatment group was less than that in control group（ P 〈0.05 orP 〈0.01）. After treatment SOD were higher and NO were lower（ P 〈 0. 05）. Conclusion ： Mengshi Ditan Decoction has therapeutic effect for schizophrenia. The therapeutic effect of integrated Chinese and western medicine treatment is superior to western medicine with less adverse effect and shorter treatment course.