丹参注射液联合黄芪注射液治疗妊娠高血压综合征临床疗效分析

Therapeutic Analysis of Salvia Miltiorrhiza-Injection Combination Milkvetch Root-Injection on Treating Pregnancy-Induced Hypertension Syndrome

目的:分析丹参注射液联合黄芪注射液治疗妊娠高血压综合征的临床疗效。方法:239例妊娠高血压综合征患者随机分为治疗组122例(采用丹参注射液联合黄芪注射液静脉点滴和常规西药治疗)和对照组117例(采用常规西药治疗),观察两组患者治疗后血压、24h尿蛋白量下降幅度,胎心异常、新生儿窒息、剖腹产、产后出血发生率以及治疗前后血浆血栓素B2(TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)的变化,并判断疗效。结果:治疗组舒张压、收缩压以及24h尿蛋白量的降幅均明显高于对照组(P<0.05或P<0.01);胎心异常、新生儿窒息和剖腹产比例均明显低于对照组(P<0.05),临床总有效率为90.9%,明显优于对照组(P<0.01);两组治疗后血浆6-keto-PGF1α含量较治疗前显著升高,TXB2含量及TXB2/6-keto-PGF1α比值较治疗前显著降低(P<0.05或P<0.01);与对照组比较,治疗后治疗组血浆6-keto-PGF1α、TXB2含量和TXB2/6-keto-PGF1α比值均有统计学差异(P<0.05)。结论:丹参注射液联合黄芪注射液可改善妊娠高血压综合征患者临床表现,减少胎心异常、新生儿窒息、剖腹产的发生率,其作用机制与调节6-keto-PGF1α和TXB2含量有关。

Objective ： To analysis the therapeutic effect of salvia miltiorrhiza - injection combination milkvetch root - injection on treating pregnancy - induced hypertension syndrome. Methods ：239 case of patients with pregnancy - induced hypertension syndrome devoded into two groups randomly, 122 cases of the treatment group was treated by salvia miltiorrhiza- injection combination milkvetch root- injection and routine western medicine, and 117 cases of the control group was treated by routine western medicine,to observe the drop amplitude of blood pressure and Urine protein in one day, fetal heart abnormality,apnoea neonatornm, abdominal delivery and postpartum hemorrhage, and the content of TXB2 and 6 -keto- PGF1α in blood plasma before and after treatment, and judge curative effect. Results ：Compared with control group ,the drop amplitude of blood pressure and Urine protein in one day were higher obviously（ P 〈 0.05 or P 〈 0.01 ） and the ratio of fetal heart abnormality,apnoea neonatorum and abdominal delivery were lower obviously （ P 〈 0.05）in treatment groups; Compared with before treatment, the content of 6 - keto - PGF1α in blood plasma were increased, and the content of TXB2 ,the ratio of TXB2 and 6 - keto - PGF1α were decreased obviously in two groups（ P 〈 0.05 or P 〈 0.01 ） ;compared with control group, the neurologic impairment scores, the content of TXB2,6 -keto - PGF1α and the ratio of TXB2 and 6 - keto - PGF1α were different obviously in treatment groups（ P 〈 0.05）. Conclusion ： Salvia miltiorrhiza - injection combination milkvetch root - injection could improve clinical situation of patients with pregnancy - induced hypertension syndrome and reduce incidence of fetal heart abnormality, apnoea neonatorum and abdominal delivery through modulating the content of TXB2 and 6 - keto - PGF1α.