丹参注射液联合黄芪注射液对妊娠高血压综合征患者自由基代谢的影响

Effect of Salvia Miltiorrhiza Injection Combination Milkvetch Root Iinjection on Free Radical Metabolism in Patients of Pregnancy Induced Hypertension Syndrome

目的观察丹参注射液联合黄芪注射液对妊娠高血压综合征患者血清超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)的影响。方法将239例妊娠高血压综合征患者随机分为治疗组122例(采用丹参注射液联合黄芪注射液静滴和常规西药治疗)与对照组117例(采用常规西药治疗);比较两组患者治疗后血压、24h尿蛋白量降幅、胎心异常、新生儿窒息、剖腹产、产后出血发生率以及血清SOD、MDA、NO的变化。结果治疗组舒张压、收缩压以及24h尿蛋白量的降幅均明显高于对照组;胎心异常,新生儿窒息和剖腹产比例均明显低于对照组;两组治疗后SOD活性、NO含量较治疗前显著升高,MDA含量较治疗前显著降低,而治疗组改善更为显著。结论丹参注射液联合黄芪注射液可改善妊娠高血压综合征患者临床表现,减少胎心异常、新生儿窒息、剖腹产的发生率,其作用机制与调节自由基代谢有关。

Objective： To observe the effect of salvia mihiorrhiza injection combination milkvetch root injection on the activity of superoxide dismutase（SOD）and the content of Malondialdehyde（MDA） and mtrogen monoxidum（NO） in patients of pregnancy induced hypertension syndrome. Methods： 239 cases of patients with pregnancy induced hypertension syndrome divided into two groups randomly. 122 cases of the treatment group was treated by salvia mihiorrhiza injection combination milkveteh root injectaon and routine western medicine, and 117 cases of the control group was treated by routine western medicine. The drop amplitude of blood pressure and Urine protein in one day, fetal heart abnormality, apnoea neonatorum,abdominal delivery and postpartum hemorrhage,and the activity of SOD and the content of MDA and NO in blond plasma were recorded before and after treatment. Results： Compared with control group, the drop amplitude of blood pressure and Urine protein in one day were higher obviously and the ratio of fetal heart abnormality, apnoea neonatorum and abdominal delivery were lower obviously in treatment groups. Compared with before treatment, the activity of SOD and the content of NO in blood plasma were increased, and the content of MDA were decreased obviously in two groups. Compared with control group,the activity of SOD, the content of MDA and NO were different obviously in treatment groups. Conclusion： Salvia mihiorrhiza injection combination milkveteh root injection could improve clinical situation of patients with pregnancy- induced hypertension syndrome and reduce incidence of fetal heart abnormality, apnoea neonatorum and abdominal delivery through modulating the free radical metabolism