健脾康复丸对二甲基肼诱导大鼠大肠癌的预防作用

Prevention of Jianpikangfu Pill Against Colorectal Cancer in Rats lnduced by Dimethylhydrazine

目的探讨健脾康复丸对二甲基肼(DMH)诱导的大鼠大肠癌的预防作用。方法用1,2-二甲基肼腹腔注射诱导大鼠发生大肠癌,观察健脾康复丸对诱癌率及胸腺指数和脾指数等的影响。结果本研究用DMH成功诱导大鼠大肠癌模型,正常对照组未见肿瘤发生,模型对照组诱癌率83.33%,健脾康复丸高剂量组诱癌率40.00%,明显低于模型对照组;健脾康复丸高剂量组胸腺指数和脾指数均明显大于模型对照组及希罗达对照组,健脾康复丸低剂量组胸腺指数亦明显大于希罗达对照组。结论健脾康复丸对DMH诱导的大肠癌有预防作用,并能改善机体免疫功能。

Objective： To observe the prevention of Jianpikangfu Pill against colorectal cancer in rats induced by 1, 2 -dimethylhydrazine（DMH）. Methods： The colorectal cancer model induced by DMH intraperitoneal injection. The effect of Jianpikangfu Pill on the occurrence rate of colorectal cancer and on spleen index and on thymus index were observed. Results： The colorectal cancer model was successfully established in this experiment. The cancer inducing rate of model control group was 83.33% ,while that of Jiangpikangfu Pill high dose group was 40.00%. the difference between the two groups was statistically significant. The thymus and spleen index of Jiangpikangfu Pill high dose group were markedly large than that of model control group and capecitabine control group. The thymus index of Jianpikangfu Pill low dose group was markedly large than that of capecitabine control .group al- so. Conclusion： Jinanpikangfu Pill have the effects of preventing colorectal cancer induced by DMH and it can improve organism＇s immune function.