螺噻唑并咪唑类化合物的合成

Synthesis of Spiro thiazole imidazole Compound

由螺［５．５］十一烷－３－酮与硫脲在碘的存在下反应，生成了４，５－二氢螺［苯并［ｄ］噻唑－６－（７Ｈ），１′－环己烷］－２－胺（３），３与溴甲基苯基甲酮在苯中缩合得到相应的酮４ａ～４ｃ，然后在醇中加热环化生成二氢螺［咪唑并［２，１－ｂ］苯并［ｄ］噻唑］化合物５ａ～５ｃ。新化合物５ａ～５ｃ的分子组成及结构经元素分析、１ＨＮＭＲ、１３ＣＮＭＲ证实，其中产物５ｂ的分子结构经Ｘ－射线衍射晶体分析确认。

Dihydrospirothiazole 6(7H),1′ cyclohexane] 2 amine (3) prepared by reaction of spiroundecane 3 one with thiourea in the presence of iodine, was condensed with bromomethyl phenyl ketones in benzene to give ketones 4a￣4c, which on heating in ethanol undergo cyclization to give 2 (p chlorophenyl) 5,8 dihydrospiro[imidazo(2,1 b)benzothiazole 7(6H),1′ cyclohexane] (5). All new structures were unambiguously confirmed by elemental analyses, 1H NMR, 13 C NMR spectra.