N^4-取代缩氨基硫脲衍生物的合成

Synthesis and Antibactiral of Derivatives of N 4 Substituted Thiosemicarbazone

以Ｎ４－取代氨基硫脲与尿嘧啶－１－乙醛反应，合成了６种Ｎ４－取代氨基硫脲衍生物，并进行了抗菌活性测试。结果表明，当Ｎ４－取代基为对氯苯基（Ⅲ６）时，具有较高的抑制枯草杆菌活性，对八叠球菌、白色念珠菌、黄曲霉菌亦有一定活性。

Six N 4 substituted thiosemicarbazones were prepared by condensation of N 4 substituted thiosemicarbazide with uracil 1 acetaldehyde. The inhibiting activities of all the compounds against six kinds of bacteria and two kinds of fung were determined preliminarily. The results showed that compound Ⅲ 6 possessed higher inhibiting activity against B. Subtilis, and some inhibiting activities against S. Lutea, M. Albicans and A. Flavus.