氢化可的松在氯仿-水体系中分配系数的预测

Prediction of Distribution for Hydrocortisone in Chloroform Water System

氢化可的松在氯仿－水体系中分配系数的预测汤志刚胡熙恩朱永贝睿（清华大学核能技术设计研究院，北京１０２２０１）关键词氢化可的松液－液平衡分配系数Ｍａｒｇｕｌｅｓ方程氯仿１前言Ｗｉｃｈｔｅｒｌｅ和Ｆｏｌｐｒｅｃｈｔｏｖａ［１］曾利用碘在氯仿和水中的溶解度...

The melting point temperature and melting heat of hydrocortisone were measured. The solubilities of hydrocortisone in two phases were used to predict the distribution coefficients of hydrocortisone in chloroform water system according to binary 2 suffix Margules equation over the temperature range of 288￣303K. The results were compared with the experimental data and it is shown that precision of prediction is good. Moreover, relation between the ratio of hydrocortisone solubilities in two phases and distribution coefficient of hydrocortisone was discussed.