遗传相关性大肠癌14例临床分析

Clinical analysis of 14 cases of the large intestine carcinoma with genetic relativity

目的了解遗传相关性大肠癌的临床特点。方法对120例大肠癌进行家系调查,对其中14例具有遗传相关性大肠癌的家系临床资料进行分析。结果具有遗传相关性大肠癌占同期大肠癌的11.67%,大肠癌一家族中有一级亲属两人以上发病的6个家族,占总的发病家族的1/20,而6个发病家族的发病人数为14人。占6个大肠癌家族一级亲属总人数(84人)的1/6。结论具有遗传背景的大肠癌家族成员是不可忽视的易感人群。

Objective ： To understand the clinical characteristic of larger intestine carcinoma with genetic relativity. Methords ： We investigate ancestry of 120 cases larger intestine carcinoma, and analysis clinical data of 14 cases with genetic relativity. Results： The percent of larger intestine with genetic relativity 11.67%. There were 6 family with larger intestine carcinoma family , the percent was 1/20, and suffering number was 14 in large intesting carcinoma family. Conclution： The family number are unneglectable with genetic relativity larger intestine carcinoma, we should improve the acquaintanceship for the essentiality to investigate larger intestine carcinoma family.