手性稀土配合物催化的亚膦酸酯对醛的不对称加成(Pudovik)反应研究

Enantioselective Addition (Asymmetric Pudovik Reaction) of Dialkyl Phosphite to Aldehydes Catalyzed by Chiral La Li 6,6′ diphenyl binaphthol Complex

手性稀土配合物催化的亚膦酸酯对醛的不对称加成（Ｐｕｄｏｖｉｋ）反应研究钱长涛黄太生（中国科学院上海有机化学研究所金属有机化学开放实验室上海２０００３２）关键词对映选择性加成Ｐｕｄｏｖｉｋ反应手性镧配合物α－羟基膦酸酯分类号Ｏ６４３．３２光学纯的α－羟...

La Li 6,6′ diphenyl binaphthol complex, prepared in situ from ( S ) dilithium 6,6′ diphenyl binaphthooxide, lanthanum trichloride, sodium hydroxide and water at room temperature in tetrahydrofuran, could effectively catalyzed the reaction of dialkyl phosphite with aldehydes to give α hydroxy phosphonates in high yields with modest enantioselectivity (39%-74% e.e.). Further studies on the asymmetric reaction is now in progress.