不对称催化氢化制备(S)-(+)-萘普生 Ⅱ.不对称氢化反应条件

Catalytic Asymmetric Hydrogenation to Produce ( S ) (+) Naproxen Ⅱ. Reaction Conditions of Asymmetric Hydrogenation

不对称催化氢化制备（Ｓ）－（＋）－萘普生１）Ⅱ．不对称氢化反应条件赵培庆宫照阳（中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室兰州７３００００）关键词萘普生不对称催化氢化反应条件分类号Ｏ６４３．３２不对称催化是分子催化研究中的前沿领域之...

The effects of reaction conditions such as reaction pressure, temperature, time, and the amount of catalyst on the optical yield of catalytic asymmetric hydrogenation to produce ( S ) (+) naproxen were investigated. The results show that a higher optical yield can be obtained at a higher reaction pressure and a lower reaction temperature, and it can be affected by reaction time and the amount of catalyst as well. In the meantime, the following reaction conditions were found to be appropriate: [RuCl 2( S BIPHEN)] 2(NEt 3) used as a catalyst, triethylamine as a promater (the organic base, Sub./NEt 3: 1), reaction temperature -5-0℃, reaction H 2 pressure 6-8 MPa, reaction time 16 h. and the molar ratio of subtrate to catalyst 200. Under these conditions, the optical yield of the asymmetric hydrogenation of 2 (5 halo 6 methoxy 2 naphthyl) acrylic acid was above 95%e.e.