血清新蝶呤及高敏C反应蛋白与动脉粥样硬化性脑梗死预后的相关性

Relationship between serum neoptrin as well as hypersensitive C reactive protein and the prognosis of atherosclerosis cerebral infarction

目的探讨血清新喋呤及高敏C反应蛋白(HS-CRP)与动脉粥样硬化性脑梗死(ACI)病情严重程度及预后的关系。方法采用酶联免疫吸附测定法测定57例ACI和29例腔隙性脑梗死(LI)患者发病24 h内、72h、7 d血清新蝶呤及HS-CRP水平,并与正常组32例体检者进行对照。结果ACI组与LI组急性期血清新蝶呤及HS-CRP在发病24 h内升高,72 h达到最高,7 d时呈现下降趋势但仍高于正常;ACI组血清新蝶呤及HS-CRP高于LI组,LI组血清新蝶呤及HS-CRP高于正常对照组,差异有统计学意义(P<0.05);ACI组患者神经系统功能缺损程度评分与患者血清新蝶呤及HS-CRP水平呈正相关。结论血清新蝶呤及HS-CRP呈动态变化趋势,提示ACI的发生是一个免疫炎症过程,可作为诊断和预后的指标。

Objective To investigate the relationship between serum neoptrin as well as hypersensitive C reactive protein（HS-CRP） and the prognosis of atherosclerosis cerebral infarction（ACI）. Methods Serum neoptrin and HS-CRP were detected in 57 cases of ACI and 29 cases of lacunar infarction（LI） by ELISA at 24 h, 72 h, and 7 d respectively, and compared with 32 cases of normal physical examinees. Results In ACI and LI groups, serum neoptrin and HS-CRP presented an increased tendency within 24 h from onset, and reached their high peaks at 72 h, but became to decrease at 7 d. Serum neoptrin and HS-CRP in ACI group were positively correlated with the grading of nervous system dysfunction. Conclusion The changes of serum neoptrin and HS-CRP indicate that the pathogenesis of ACI is an immune inflammatory process, and can be used as diagnostic and prognostic indexes.