4-羟基-2,2,6,6-四甲基哌啶对肾性高血压大鼠左室重塑的保护作用及机制探讨
摘要
高血压并发的左室重塑主要表现为左心室肥厚和心肌纤维化。在高血压早期是适应性的代偿反应，但长期过量的负荷必然导致失代偿，终至心力衰竭。大量的流行病学资料证明，左室重塑是心血管系统疾病发病率和病死率的独立危险因素。氧化应激（OS，oxidative stress）是指细胞暴露于高浓度O2分子或O2的化学衍生物即反应氧族（ROS，reactive oxygen species）而引起的细胞损伤，
出处
《中国药物与临床》
CAS
2008年第9期719-721,共3页
Chinese Remedies & Clinics
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