帕金森病患者睡眠障碍临床分析

Clinical analysis of dyssomnia in Parkinson patients

目的分析帕金森病(PD)患者睡眠障碍发生情况及可能影响因素。方法采用统一帕金森病评定量表(UPDKS)、Hoehn-Yahr分级表、汉密尔顿抑郁量表、改良Webster评分、匹兹堡睡眠质量指数(PQSI)、爱泼沃斯思睡量表(ESS)及简明精神状态量表(MMSE)对PD患者病情及睡眠情况进行评定,并与对照组进行对照分析。结果62例PD患者中53例(85.5%)有睡眠障碍,其中失眠46例(86.8%),异态睡眠39例(73.6%),白天睡眠障碍36例(69.2%),与对照组对比均有显著差异(P<0.05)。结论PD患者睡眠障碍较为常见,主要表现为失眠、异态睡眠、日间嗜睡、睡眠发作等,其程度与抑郁、病情严重度及多巴胺能药物剂量等有关。

Objective To analyze the occurrence and possible influencing factor of Parkinsonian dyssomnia. Methods We evaluated the patients contracted Parkinson＇s disease on pathogenetic condition and sleep quality with unified Parkinson disease rating scale（UPDRS）, Hoehn-Yahr grade scale, Hamilton＇s depression scale, improved Webster score, Ittsburgh sleep quality index （PSQI）, Epworth Sleepiness Scale（ESS）, mini-mental state examination（MMSE）, and compared with control group. Results In 62 Parkinson patients, 53 cases had dyssomnia（85.5%）, 46 patients were insomnia（86.8%）, 39 patients were parasomnias（73. 6%）, 36 patients were daytime dyssomnia （69. 2%）, there was significant difference compared with control group（P〈0. 05）. Conclusion Parkinsonian dyssomnia is relatively common, the main manifestation includes insomnia, parasomnias, daytime drowsiness, narcoleptic attack and so on. The degree is concerned with athymia, pathogenetic condition severity and dopaminergic dosage, etc.