碳酸镧在CA、UDS和MN试验中的抗诱变作用

Study on Antimutagenic Effect of Lanthanum Carbonate in CA Test,UDS Test and MN Test

应用人胚纤维母细胞（ＨＥＦ）染色体畸变（ＣＡ）试验、非程序ＤＮＡ合成（ＵＤＳ）试验和小鼠骨髓细胞微核（ＭＮ）试验，研究了碳酸镧对短波紫外线（ＵＶ）、盐酸氮芥（ＮＨ２ＨＣ１）、亚砷酸钠（ＮａＡｓＯ２）和环磷酰胺（ＣＰ）致突变作用的影响，从遗传学角度评估了碳酸镧的抗诱变作用。结果表明：碳酸镧在ＵＶ、ＮＨ２ＨＣｌ和ＣＰ诱导的不同遗传终点中，显示了不同程度的诱变抑制作用。但碳酸镧对ＮａＡｓＯ２诱导的ＣＡ效应仅有下降趋势，而无统计学意义，故认为其抗诱变作用可能有某种专属性。

Antimutagenic effect of Lanthanum carbonate [La 2(CO 3) 3]has been evaluated by means of unscheduled DNA synthesis (UDS) test,chromosomal aberration (CA) test in vitro human embryofibroblast (HEF) and micronucleus (MN) test in mouse bonemarrow polychromatic erythrocyte (PCE) induced by four different mutagens,i.e.,short wave ultraviolet (UV),hydrochloric acid nitrogen mustard (NH 2HCl),arsenic sodium oxide (NaAsO 2) and cyclophosphamide (CP).The results of this study indicated that the antimutagenic effect of La 2 (CO 3) 3 was obvious in multiple antimutagenic systems in which mutation was induced by UV,NH 2HCl and CP,but the effect of La 2(CO 3) 3 on the decrease of CA frequencies induced by NaAsO 2 had no statistical significance.