深海鱼油降血脂作用量效关系的研究

Study on the Dose Effect Relationship of Hypolipidemic Effect of Deepsea Fish Oil

实验动物随机分为４组：２．５、５、１０ｇ／ｋｇ及高脂对照组，建立起大鼠实验性高脂血症模型。结果表明：大鼠ＴＧ、ＨＤＬ－ｃ水平与鱼油摄入量存在直线相关关系，鱼油能够稳定降低ＴＧ、稳定提高ＨＤＬ－ｃ。ＴＣ、ＬＤＬ－ｃ水平与鱼油摄入量无直线相关关系，２．５ｇ／ｋｇ鱼油即能使ＴＣ、ＬＤＬ－ｃ显著下降。

The dose effect relationship of hypolipidemic effect of fish oil was studied.The rats were divided into four groups:2 5 5 10g/kg and high dietary fat control group.The experimental rat model of high serum lipids was developed.The results showed that there was a linear correlation between the levels of TG,HDL c and the dosage of fish oil.Fish oil reduced TC level and elevated HDL c level steadily.But no linear correlation was observed between TC,LDL c and the dosage of fish oil.The level of TC and LDL c decreased markedly at the dosage of 2 5g/kg of fish oil.