骨质疏松症骨折愈合的电子显微镜观察

The Observation on Fracture Union of Osteoporosis Patients by Electron Microscope

本文对骨质疏松症患者股骨粗隆间骨折愈合前后,骨折部位的标本作电子显微镜观察,看到在其愈合过程中,早期的组织细胞学变化与普通的骨折愈合无明显差异。在后期,骨质疏松症患者的巨噬细胞破骨活动明显较强,吸收与破坏已形成的胶原纤维,使钙盐沉积受阻,愈合骨的强度下降。这一现象提示,对骨质疏松症骨折愈合缺陷的治疗,也许主要应集中在骨折愈合后期,设法抑制巨噬细胞破骨细胞的活性,保护已形成纤维结构,促进钙盐沉积,顺利完成模造。

We have studied the spicements from the fractured sites of the osteoporosis patients by the electron microscope, who suffered femoral intertrochanteral fractures and after the fractures union. In the early stage of the healing course, we have observed no histocytological difference between them and the ordinary ones. In the later stage the macrophages and osteoclasts in the specimens of the osteoporosis patients increase obviously their activities, destroy and absorb the formed collagenic fibres, prevent the calcipexy, and decrease the strength of the healed bone. That means: we should focus our treatment to the deficiency of the ostesporosis fracture healing on the restraining the activities of the macrophages and the ostesclasts, protecting the formed fibres, accelerating the calcipexy and fulfiling the bone remodeling in the late stage.