糖尿病患者血清生长激素水平与微血管病变的关系

The relationship between concentration of growth hormone in serum and microangiopathy in patients with diabetes mellitus.

目的了解糖尿病患者血清生长激素（ＧＨ）水平与微血管病变之间的关系，探讨糖尿病患者微血管的病变机理。方法非胰岛素依赖型糖尿病（ＮＩＤＤＭ）１４１例，胰岛素依赖型糖尿病（ＩＤＤＭ）２７例。生长激素水平和胰岛素（ＩＮＳ）均采用放射免疫法测定，血糖用氧化酶法测定。结果ＮＩＤＤＭ患者的ＧＨ无合并微血管病变患者（３．３±１．２μｇ／Ｌ）明显高于正常人（１．０±１．２μｇ／Ｌ），合并微血管病变者（５．７±１．９μｇ／Ｌ）明显高于无微血管病变者，，差异都有非常显著意义（Ｐ＜０．０１）。随病程延长，ＧＨ水平越高，微血管病变发病比例也就越高。血清ＧＨ水平与血糖呈平行关系（ｒ＝０．１７３），与ＩＮＳ间无显著相关。ＩＤＤＭ患者ＧＨ水平（６．６±３．４μｇ／Ｌ）较ＮＩＤＤＭ患者（４．６±１．８μｇ／Ｌ）还高，且均为有微血管病变者。结论ＧＨ升高可能是糖尿病患者微血管病变的重要因素之一。

Objective To study the relationship between growth hormone (GH) and microangiopathy in patients with diabetes mellitus in order to elucidate pathogenesis on microangiopathy in diabetics.Methods GH and insulin (INS) were detected by rdioimmunoassay, and blood sugar (BS) was detected by oxydase method.Results 138 NIDDM diabetics were examined. The concentration of serum GH in diabetics without microangiopathy (2.3±1.2 μg/L) was higher than in normal people (1.0±1.2 μg/L) and GH in diabetics with microangiopathy (5.74±1.94 μg/L) was higher than in diabetics without microangiopathy. The differences were significant ( P <0.01). As the history of diabetes went on, the level of GH in serum increased, and the incidence of microangiopathy increased too. The correlation of GH in serum with BS was parallel. The correlation of GH in serum with INS was not apparent. 27 IDDM diabetics were examined, their level of GH in serum (6.8±3.4 μg/L) was higher than that of NIDDM diabetics (4.6±1.8 μg/L). They were all patients with microangiopathy. Conclusion The rise of GH in serum may be an important pathogeny that causes microangiopathy in diabetics.