地西泮联合间苯三酚在产程活跃期中的应用

Effects of phloroglucinol and diazepam on the progression of labor during active phase

目的观察地西泮联合问苯三酚在分娩中对产程的影响。方法选择正常初产妇规律宫缩愿意经阴道分娩者200例，随机分为两组，每组各100例。观察组在宫口开大3cm宫缩规律时给予间苯三酚80mg宫颈注射，加地西泮10mg肌肉注射，对照组不予干预。同时观察两组的产程、分娩方式、新生儿Apgar评分及产后2h阴道流血量等情况。结果观察组疼痛程度Ⅰ、Ⅱ、Ⅲ级分别为82、16、2例，对照组分别为30、58、12例，两组比较差异有统计学意义（P〈0．01）；观察组总产程和第一产程均较对照组明显缩短（P〈0．05），顺产率明显高于对照组（P〈0．05）。阴道流血量、新生儿Apgar评分及新生儿出生体重等比较差异均无统计学意义（P〉0．05）。结论地西泮联合间苯三酚能明显缩短产程，减轻分娩疼痛，对产妇及新生儿无不良影响，值得推广使用。

Objective To observe the effects of phloroglucinol and diazepam on the progression of labor. Methods Two hundred normal primipara without indication of cesarean were randomly divided into intervention group and control group. When the cervix dilated 3 era, the intervention group was given 80 mg phloroglucinol by injection of the cervix and 10 mg diazepam by injection of muscle, the control group was not given any drug. The length of labor stage, the different ways of labor, scores of neonate, volume of bleeding during 2 hours after labor of the two groups were observed. Results The pain degree of Ⅰ ,Ⅱ, Ⅲ grade was 82, 16, 2 cases in intervention group, but 30, 58, 12 cases in control group, there was significant difference between the two groups （P 〈 0.01 ）. The length of total labor stage and the first labor stage in intervention group were significant lower than those in control group （P 〈 0.05 ）, the rate of spontaneous delivery in intervention group was higher than that in control group （P 〈 0.05 ）, the others had no significant difference between the two groups （P 〉 0.05）. Conclusions Phloroglucinol and diazepam can decurtate the length of labor stage and lessen pain and have no effects on both mother and newborn, It is worthwhile to spread the drugs in clinical practice.