雌激素受体水平对老年乳腺癌预后的影响

The effect of estrogen receptor level on the prognosis of the elderly breast cancer patients

目的探讨雌激素受体水平对老年乳腺癌预后的影响及术后治疗的指导作用。方法根据雌激素受体（ＥＲ）水平，将收治的１３４例老年女性乳腺癌分成ＥＲ（＋）和ＥＲ（－）两组，按Ｋａｐｌａｎ－Ｍｅｉｅｒ法计算，并按时序检验比较两生存曲线的趋势。结果ＥＲ（＋）组８８例，中位随访时间为９２．５个月（范围５５～１２６个月），１８例出现复发转移，复发转移率为２０．５％；ＥＲ（－）组４６例，中位随访时间为８５．５个月（范围５７～１２１个月），１９例出现复发转移，复发转移率为４１．３％。经统计学处理，两组间差异有显著性，ＥＲ（＋）组术后复发转移率明显低于ＥＲ（－）组。结论雌激素受体是老年女性乳腺癌的一个预后参考因素。

Objective To evaluate the effect of estrogen receptor (ER) on the prognosis of the elderly female breast cancer patients and the guidance for their post operation therapy. Methods 134 cases of the elderly female breast cancer patients (≥60 year old) were divided into two groups depending on their ER level. Kaplan Meier method was used to estimate disease free servival (DFS) rate from the date of surgery. Results There were 88 patients in ER(+) group and 46 patients in ER(-) group. The medium follow up of the ER(+) and the ER (-) group was 92.5 and 85.5 months, respectively. The incidence of recurrence and metastasis was 20.5% (18/88) in the ER (+) group and 41.3% (19/46) in the ER (-) group ( P <0.02).Conclusion Estrogen receptor is a reference factor to predict prognosis of breast cancer in elderly patients.