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丙种球蛋白在抗磷脂综合征所致复发性流产中的应用 被引量:2

Application of Intravenous Gamma Globulin in Treatment of Recurrent Abortion Caused by Antiphospholipid Syndrome
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摘要 目的:探讨静脉注射丙种球蛋白(IVIG)治疗抗磷脂综合征(APS)所致复发性流产的临床疗效,比较IVIG与传统治疗及阿司匹林+强的松+潘生丁治疗APS所致复发性流产的疗效差异。方法:248例APS所致复发性流产患者,随机分为4组;组1:传统保胎治疗(54例,黄体酮+HCG等);组2:阿司匹林+强的松+潘生丁(84例);组3:IVIG(38例);组4:阿司匹林+强的松+潘生丁联合IVIG(72例)。观察疗效、妊娠结局、不良反应及妊娠并发症。结果:IVIG组(79.76%)与阿司匹林+强的松+潘生丁组(73.68%)妊娠成功率相比,差异无显著性(P>0.05),此二组与传统保胎治疗组(18.52%)妊娠成功率相比,差异有显著性(P<0.05)。联合用药组(95.83%)妊娠成功率与其它三组相比,差异有显著性(P<0.05)。任意两组妊娠并发症无显著差异(P>0.05)。结论:阿司匹林+强的松+潘生丁联合IVIG治疗APS所致复发性流产,妊娠成功率较高,并发症无明显增加。 Objective:To investigate the therapeutic efficacy of immune globulin intravenous(IVIG)for recurrent spontaneous abortion caused by antiphospholipid syndrome(APS),and compare with the difference of therapeutic efficacy between in IVIG, traditional therapy and aspirin+ prednisone+ persantine therapy.Methods:Two hundred and forty-eight patients diagnosed as recurrent spontaneous aborition caused by APS were divided into four groups:group 1:traditional therapy(n=54,gesterol and HCG);group 2: aspirin+prednisone+persantine therapy(n=84);group 3:WIG therapy(n=38);group 4:combine aspirin+prednisone+persantine with WIG(n=72).Results:There were significant differences in pregnancy outcomes between 1 and other groups(P〈0.05),but no statistical significance between 2 and 3(P〉0.05);There was no statistical significance in Gestational diseases between each two groups(P〉0.05). Conclusions:IVIG may act as an effective and safe method for treatment recurrent spontaneous abortion caused by APS.
出处 《现代生物医学进展》 CAS 2008年第8期1478-1480,共3页 Progress in Modern Biomedicine
关键词 静脉注射丙种球蛋白 免疫 抗磷脂综合征 复发性流产 intravenous immune globulin immune anti-phospholipid syndrome recurrent spontaneous abortion
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