丙种球蛋白在抗磷脂综合征所致复发性流产中的应用

Application of Intravenous Gamma Globulin in Treatment of Recurrent Abortion Caused by Antiphospholipid Syndrome

目的:探讨静脉注射丙种球蛋白(IVIG)治疗抗磷脂综合征(APS)所致复发性流产的临床疗效,比较IVIG与传统治疗及阿司匹林+强的松+潘生丁治疗APS所致复发性流产的疗效差异。方法:248例APS所致复发性流产患者,随机分为4组;组1:传统保胎治疗(54例,黄体酮+HCG等);组2:阿司匹林+强的松+潘生丁(84例);组3:IVIG(38例);组4:阿司匹林+强的松+潘生丁联合IVIG(72例)。观察疗效、妊娠结局、不良反应及妊娠并发症。结果:IVIG组(79.76%)与阿司匹林+强的松+潘生丁组(73.68%)妊娠成功率相比,差异无显著性(P>0.05),此二组与传统保胎治疗组(18.52%)妊娠成功率相比,差异有显著性(P<0.05)。联合用药组(95.83%)妊娠成功率与其它三组相比,差异有显著性(P<0.05)。任意两组妊娠并发症无显著差异(P>0.05)。结论:阿司匹林+强的松+潘生丁联合IVIG治疗APS所致复发性流产,妊娠成功率较高,并发症无明显增加。

Objective：To investigate the therapeutic efficacy of immune globulin intravenous（IVIG）for recurrent spontaneous abortion caused by antiphospholipid syndrome（APS）,and compare with the difference of therapeutic efficacy between in IVIG, traditional therapy and aspirin＋ prednisone＋ persantine therapy.Methods：Two hundred and forty-eight patients diagnosed as recurrent spontaneous aborition caused by APS were divided into four groups：group 1：traditional therapy（n=54,gesterol and HCG）;group 2： aspirin＋prednisone＋persantine therapy（n=84）;group 3：WIG therapy（n=38）;group 4：combine aspirin＋prednisone＋persantine with WIG（n=72）.Results：There were significant differences in pregnancy outcomes between 1 and other groups（P〈0.05）,but no statistical significance between 2 and 3（P〉0.05）;There was no statistical significance in Gestational diseases between each two groups（P〉0.05）. Conclusions：IVIG may act as an effective and safe method for treatment recurrent spontaneous abortion caused by APS.