支气管哮喘合并慢性鼻窦炎临床特点的研究

Study on clinical features in bronchial asthma with chronic sinusitis

目的探讨支气管哮喘（简称哮喘）患者合并慢性鼻窦炎的临床特点。方法入选患者完善鼻窦CT扫描，根据症状及鼻窦CT扫描分为慢性鼻窦炎组与非慢性鼻窦炎组，两组均完善肺功能、鼻咽分泌物病毒抗原、血清病毒IgM特异性抗体检查、免疫球蛋白IgG、IgA、IgM和T细胞亚群。结果35例哮喘患者中慢性鼻窦炎组病毒阳性者为64．7％（11／17），非慢性鼻窦炎组病毒阳性者为22．2％（4／18）（P〈0．05）。慢性鼻窦炎组与非慢性鼻窦炎组在免疫球蛋白IgG、IgA、IgM、T细胞亚群及肺通气功能指标比较差异无统计学意义。结论哮喘患者合并慢性鼻窦炎病毒阳性率很高，提示慢性鼻窦炎可能使哮喘患者更易受到病毒的侵犯，因此哮喘患者合并慢性鼻窦炎更要重视对病毒感染的预防。

Objective To investigate the clinical features in bronchial asthma（asthma） with chronic sinusitis. Methods Thirty-five patients of asthma underwent CT scanning of nasal sinuses, immunoglobulin G, A, M, T-lymphocyte subgroups, spirometry, and virus antigen, the specific IgM virus antibody. The patients with asthma were divided into two groups according to complicating with chronic sinusitis or not. Results The viruses were positive in 11 （64.7 % ） patients of asthma with chronic sinusitis. The viruses were positive in 4 （22.2%） patients of asthma without chronic sinusitis（ P d0.05）. No difference was found between chronic sinusitis group and none-chronic sinusitis group of patients with asthma in level of immunoglobulin G, A, M, T-lymphocyte subgroups, FEV1%, FEV1/FVC, FVC%. Conclusions The virus positive of patients of asthma with chronic sinusitis is higher than that of patients of asthma without chronic sinusitis. More attention should be put on the patients of asthma with chronic sinusitis in preventing infection with the virus.