碳纤维/碳纳米管增强磷酸钙生物复合材料的血液相容性研究

Antithrombogenicity Investigations on Calcium Phosphate Bone Cement Composites Strengthened by Carbon Fibers and Carbon Nanotubes

目的:探讨以碳长纤维模拟骨组织中的胶原纤维束,碳纳米管弥散分布在骨水泥基质中所制备的仿生复合材料的血液相容性。方法:采用血小板静态浸渍黏附、聚集实验法,通过扫描电镜(SEM)观察复合材料表面、粗糙断面及气孔内的血栓形成情况,对其血液相容性进行研究。结果:以两种碳材料为增强相制备的复合材料与血液接触后,在材料光滑的表面、粗糙的断面及气孔内、以及碳纤维与碳纳米管的表面,由于纤维蛋白原的吸附量较少使血小板难以黏附、聚集,因此,在材料表面未能形成白血栓。结论:以碳纤维和碳纳米管为增强相制备的骨水泥生物复合材料具有良好的血液相容性。

Objective： To investigate antithrombogenicity of bone cement composite made by long carbon fibers simulating collagen fibers in bone structure and carbon nanotubes which were dispersed in bone cement. Methods： Platelets adhesion and concentration test and SEM were carried out to observe thrombus on materials smooth or coarse surfaces and inside their pores. Results： It was shown that when blood met composites, on their smooth or coarse surfaces？inside pores and exteriors of carbon fibers and carbon nanotubes, few fibrinogens were absorbed, then less platelets could concentrated on them to form thrombus. Conclusion： These composites strengthened by carbon fibers and nanotubes showed good antithrombogenicity.