sHLA-G在子痫前期患者的表达及意义

The Significance and Expression of Soluble HLA-G Protein in Preeclampsia Serum

目的:检测子痫前期患者sHLA-G水平,探讨母血sHLA-G的水平和妊娠高血压疾病的关系。方法:采用酶联免疫吸附法检测20例正常孕妇晚期和20例子痫前期患者血清sHLA-G水平。结果:在正常妊娠组sHLA-G血清中的水平为10.72±3.40ng/mL;子痫前期组为9.46±5.10ng/mL。子痫前期组sHLA-G水平明显低于正常妊娠晚期组,差异有显著性意义(P<0.05)。结论:sHLA-G可能与子痫前期患者的发病有关系。

Objective： To detect the serum volume of soluble HLA-G （sHLA-G） in preeclampsia, and to explore the relation between soluble HLA-G and the preeclampsia. Methods： Serum samples were collected from 40 pregnant women （normal group 20 cases, preeclampsia group 20 cases ）, sHLA-G levels were determined with enzyme-linked immunosorbent assay （ ELISA ）, Results： The average of sHLA-G in preeclampsia group before labor is 9.46：1：5.10 ng/mL, significantly lower than that of the normal group （ 10.72± 3.40ng/mL） （P〈0,01）. Conclusions： sHLA-G may play important roles during the development of preeclampsia, it may be a serum predictor with the development of preeclampsia,