溃疡性结肠炎对凝血-纤溶系统激活现象的探讨

Study of the Activations of Coagulation-Fibrinolysis System in Patients with Ulcerative Colitis

目的:通过对活动期和缓解期溃疡性结肠炎(UC)患者凝血和纤溶系统各指标的检测和对比,探讨肠炎对凝血-纤溶系统的激活作用。方法:以20名缓解期溃疡性结肠炎患者为对照,检测20名活动期溃疡性结肠炎患者体内凝血和纤溶系统各指标,包括血小板计数、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、凝血酶原时间(PT)、凝血因子Ⅻ、Ⅺ、Ⅹ、Ⅸ、Ⅷ、Ⅶ、Ⅴ、Ⅱ,纤维蛋白原和D二聚体(D-D)。结果:活动期溃疡性结肠炎患者体内凝血因子Ⅺ、Ⅹ、Ⅸ、Ⅷ、Ⅴ、Ⅱ因子以及血浆纤维蛋白原、D-二聚体水平显著高于非活动期患者,其他指标没有显著差别。结论:活动期溃疡性结肠炎患者凝血-纤溶系统处于激活状态,提示肠炎可以激活凝血-纤溶系统。

Objective： To evaluate the hyper states of coagulation in Ulcerative Colitis （UC）by comparing activations of coaguta- tion-fibrinolysis system in patients with active UC. Methods： Twenty patients with active UC were studied, 20 patients with inactive UC served as controls. We investigated the activation of the coagulation-fibrinolysis system, including platelet counts, activated partial thromboplastin time （APTT）, thrombin time （TT）, prothrombin time （PT）, activated factors Ⅻ、Ⅺ、Ⅹ、Ⅸ、Ⅷ、Ⅶ、Ⅴ、Ⅱ., fibrinogen and D-Dimer. Results： Activated factorsⅪ、Ⅹ、Ⅸ、Ⅷ、Ⅴ、Ⅱ and fibrinogen, D-Dimer were significantly elevated in patients with active UC compared to those in patients with inactive UC. There was no significant difference between the two groups in the other indexes. Con- clusion： The results of this study indicated that the coagulation-fibrinolysis system was activated in patients with active bowel inflamma- tion such as active UC, which points out enteritis can activate coagulation-fibrinolysis system.