细胞生长因子与创伤愈合

Cell Growth Factors and Wound Healing

创伤愈合是一个复杂的过程,传统将这一过程分为血凝期、炎症期、增值期、组织重构四个相互重叠的时期。多种细胞生长因子参与了这一过程,这些细胞因子包括EGF、bFGF、VEGF、PDGF等。本文就创伤愈合过程以及其涉及的细胞生长因子的生物学特性、创伤时的表达情况、对创面愈合的促进作用、应用前景作一概述。

Tissue repair is a complex process involving blood clotting, inflammation, new tissue formation, and finally tissue remodeling. Many growth factors such as EGF, bFGF, VEGF, PDGF were involved in the process. This review summarized the four growth factors effect on the process of wound healing and the characteristic, profile of expression and promoting wound healing, and finally we discussed the perspective of them.