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拉米夫定与干扰素联合应用与单独应用治疗慢性乙型肝炎的疗效比较

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摘要 目的观察拉米夫定(LAM)与干扰素(IFN)联合用药与单独用药治疗慢性乙型肝炎的疗效。方法将210例慢性乙型肝炎患者随机分为3组:LAM组单予LAM治疗,IFN组予重组人α-2b干扰素治疗,联合组予LAM和重组人α-2b干扰素治疗,3组疗程均为12个月。结果经治疗12个月后,LAM组和IFN组血清HBeAg/抗-HBe转换率和HBV-DNA总转阴率均低于联合组(P均<0.05)。结论干扰素与拉米夫定联合抗病毒治疗,HBeAg/抗-HBe转换率及HBV-DNA转阴率较高,并对于延迟及减少YMDD变异、防止耐药发生而提高疗效起重要作用。
作者 朱水龙
出处 《现代中西医结合杂志》 CAS 2008年第28期4403-4404,共2页 Modern Journal of Integrated Traditional Chinese and Western Medicine
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参考文献5

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二级参考文献6

  • 1Liaw YF, Leung N, Guan R,et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: an update[J]. J Gastroenterol Hepatol,2003,18(3): 239-245.
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  • 5Tatulli I, Francavilla R, Rizzo GL, et al. Lamivudine and alpha-interferon in combination for precore mutant chronic hepatitis B[J]. J Hepatol,2001,35(6): 805-801.
  • 6中华医学会传染病与,寄生虫病学分会,肝病学分会.病毒性肝炎防治方案[J].中华肝脏病杂志,2000,8(6):324-329. 被引量:14010

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