茶桑混合袋泡茶毒理学研究

The Toxicological Research of the Edible Safety of Tea and Mulberry-leaf Tea Bag

根据《保健食品检验与评价技术规范》对桑叶袋泡茶安全性进行了评价。急性毒性试验结果表明,复方内容物经口LD50>30g/kgBw;3项致突变试验结果均为阴性;大鼠30天喂养试验中,各剂量组动物生长发育良好,对体重、食物利用率无不良影响;各剂量组血常规,血清生化测定结果与对照组比较无显著差异;脏器比值与对照差异不明显。肝、心、脾、肾、胃肠、睾丸、卵巢等器官外观和组织切片与对照比均未发现实质性病理改变。结果表明桑叶袋泡茶无毒,无遗传毒性,使用安全性高。

The edible safety of mulberry-leaf tea bag was investigated according to the Standard of Health Food Test and Asses. Acute toxicity test in mice showed that LD50 was higher than 30 g/kg Bw,all three genetic tests showed negative results ,30 days feeding test showed that the outer appearance, behaviors, weights, organ coefficients, the indexes of hematology and biochemistry in rats have no significant difference comparing with the control group, besides,significant pathological changes of inherent organs were not discovered. All results suggested that mulberry-leaf tea bag has no acute toxicity,no genotoxicity,and high in edible safety.