健脾益肾颗粒剂对脾肾阳虚型慢性肾炎患者尿IL-6水平的影响

Effect of Jianpi Yishen granule on urine IL-6 level in patients with chronic nephritis

目的观察健脾益肾颗粒剂治疗慢性肾炎的临床疗效。方法将60例慢性肾炎患者随机分为治疗组(健脾益肾颗粒剂组)和对照组(肾炎四味片组)各30例,观察2组慢性肾炎患者治疗前后症状、体征、尿IL-6水平的变化。结果两组患者治疗后临床症状、体征均明显改善,与治疗前比较,差异有统计学意义(P<0.05);组间比较,对炎症介质尿IL-6治疗指标的改善治疗组优于对照组(P<0.05)。结论健脾益肾颗粒剂可改善慢性肾炎患者的临床症状、体征及炎症介质尿IL-6的水平,疗效优于肾炎四味片。

Objective To observe the clinical effect of Jianpi Yishen granule for chronic nephritis. Methods 60 patients with chronic nephritis were randomly divided into treatment group with Jianpi Yishen granule and control group with Shenyan Siwei teblet, 30 patients in each, and the changes of symptoms, physical signs and IL-6 of the patients in the two groups were observed. Results All the symptoms and physical signs in two groups were improved, and the differences between two groups were significant （P〈0.05） before and after the treatment; The effect improving the index of mediators of IL-6 in treatment group was superior than that in control group （P〈0.05）. Conclusions Both the granule and tablet can improve the linical symptoms, physical signs and the level of mediators of inflammation IL-6 for the patients, and the granules is better than the teblet.