腹腔热灌注化疗在卵巢癌治疗中的研究进展

Current status of research on intraperitoneal hyperthermic chemotherapy in treatment of ovarian carcinoma

肿瘤热疗以其无手术痛苦、无术后并发症及无化疗及放疗带来的副反应而发展成为癌症治疗的第5种方法。卵巢癌患者早期多无明显症状,多数患者就诊时已有腹腔内广泛转移。腹腔热灌注化疗将局部热疗与腹腔灌注化疗结合起来,综合利用两者的协同作用,能有效地清除游离癌细胞及微小病灶。虽然应用于卵巢癌的治疗较晚,但近年来已取得了显著的进步,为晚期、复发、耐药性和难治性肿瘤的挽救性治疗提供了新的思路和指导。该文就腹腔热灌注化疗在卵巢癌治疗中的研究近况作以综述。

Thermotherapy has become the fifth method in treatment of tumor because of its no operation pains and complications, no side effects caused by chemotherapy and radiotherapy. Patients with ovarian carcinoma usually have no distinct symptoms in early stage, most of them have had extensive metastasis in peritoneal cavity when they visited a doctor. Utilizing synergetic action of hyperthemia and chemotherapy, intraperitoneal hyperthermic chemotherapy （IPHC） eliminates free cancer cells and tiny focus of carcinoma. Although the use of IPHC in the treatment of ovarian carcinoma is late, great progress has been made already, which provids new thoughts and guidance for retrieved treatment of late-stage, recurrent, drug-resistant and refractory tumors. The article reviewed current status of research on IPHC in treatment of ovarian carcinoma.