摘要
环氧化酶(COX)是花生四烯酸代谢过程中的重要限速酶,其中COX-2是诱导型酶。COX-2及其代谢产物对动脉粥样硬化、高血压和心力衰竭等多种心血管疾病的发生、发展起着重要作用。COX-2的表达受多种转录因子调控,包括核因子κB、C/EBP、激活蛋白1和丝裂原活化蛋白激酶等。本文综述了COX-2与心血管疾病之间的关系、COX-2表达的转录调控及其影响因素。
Cyclooxygenase (COX) is a key enzyme in the metabolic process of arachidonic acid. COX-2 and its metabolic product play a key role in the occurrence and development of cardiovascular disease such as artherosclerosis,hypertension and congestive heart failure and etc. COX-2 is inducible by diverse factors such as transactivators including NF-κB, C/EBP, AP-1, MAPKs, and etc. This article reviewed the relationship between COX-2 and cardiovascular diseases and the factors associated with COX-2 transcriptional regulation.
出处
《医学综述》
2008年第18期2721-2724,共4页
Medical Recapitulate
基金
莱菔硫烷对血管内皮细胞的保护作用及机理研究(30571558)
关键词
环氧化酶
心血管疾病
转录调控
Cyclooxygenase
Cardiovascular disease
Transcriptional control