环氧化酶2与心血管疾病的关系及其转录调控

Cycloxygenase-2 in Cardiovascular Diseases and its Transcriptional Regulation

环氧化酶(COX)是花生四烯酸代谢过程中的重要限速酶,其中COX-2是诱导型酶。COX-2及其代谢产物对动脉粥样硬化、高血压和心力衰竭等多种心血管疾病的发生、发展起着重要作用。COX-2的表达受多种转录因子调控,包括核因子κB、C/EBP、激活蛋白1和丝裂原活化蛋白激酶等。本文综述了COX-2与心血管疾病之间的关系、COX-2表达的转录调控及其影响因素。

Cyclooxygenase （COX） is a key enzyme in the metabolic process of arachidonic acid. COX-2 and its metabolic product play a key role in the occurrence and development of cardiovascular disease such as artherosclerosis,hypertension and congestive heart failure and etc. COX-2 is inducible by diverse factors such as transactivators including NF-κB, C/EBP, AP-1, MAPKs, and etc. This article reviewed the relationship between COX-2 and cardiovascular diseases and the factors associated with COX-2 transcriptional regulation.