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p16甲基化在宫颈癌癌变中的作用研究 被引量：1

The Methylation Investigation of p16 Effect in Cervical Carcinomas
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摘要 p16基因又称多肿瘤抑制基因,是人们发现的第一个直接作用于细胞周期,抑制细胞分裂的基因。DNA甲基化是抑癌基因失活的机制,p16基因甲基化及其在子宫颈癌癌变中的作用机制还不清楚。本文对宫颈癌中p16基因甲基化的相关研究内容进行综述。 p16 gene is a multiple tumor suppressor. It is the first anti-oncogene which directly effects cell cycle to suppress division of cells. The mechanism of antioncogene inactivation is DNA methylation, p16 gene methylation in cervical cancer and the mechanisms are still unclear. In this paper,the related contents of methylation of p16 gene in cervical cancer were reviewed.
作者 梁月勉 何春年
机构地区 河北省人民医院病理科
出处 《医学综述》 2008年第18期2783-2785,共3页 Medical Recapitulate
关键词 P16基因 DNA甲基化 宫颈癌 p16 DNA methylation Cervical carcinomas
分类号 R737.33 [医药卫生—肿瘤]
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参考文献15

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二级参考文献20

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医学综述
2008年 第18期

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