磷酸二酯酶5参与平滑肌功能调节的机制

Involvement of Phosphodiestersae Type 5 in Regulation of Smooth Muscle Function

磷酸二酯酶5(phosphodiesterase type 5,PDE5)又称对环鸟苷酸特异的磷酸二酯酶(cGMP-specific phosphodiesterase),广泛分布于机体的平滑肌细胞中,通过对细胞内特定区域的cGMP水平的调节,参与平滑肌(收缩、舒张)状态的快速调控。现对PDE5的基因表达和酶活性的调控方式,亚细胞分布,以及在平滑肌中的调节机制和药理应用进行综述。

Phosphodiesterase type 5 （PDE5） is a cGMP-specific PDE. As a major cGMP-hydrolyzing PDE, PDE5 regulates the development of smooth muscle relaxation and has a potential value in the fields of physiology, pathophysiology and pharmocology. Herein, regulation of PDE5 expression and activity, subcellular localization and mechanisms in smooth muscle functions are reviewed. Furthermore, the clinic applications of PDE5 mechanisms are discussed.