血清胆固醇水平在妊娠合并重型肝炎预后判断中的临床意义

Clinical Significance of Serum Cholesterol in Predicting the Prognosis of Pregnancy Complicating Hepatitis Gravis

【目的】探讨血清胆固醇水平(CHOL)在妊娠合并重型肝炎预后判断中的临床意义。【方法】收集40例在我院治疗的妊娠合并重型肝炎患者的临床资料,按其预后分为存活组(22例)及死亡组(18例),回顾性分析CHOL与病情变化及预后的关系。【结果】妊娠合并重型肝炎存活组与死亡组的CHOL差异有统计学意义。CHOL≤1.6mmol/L、CHOL进行性下降或凝血酶原活动度(PTA)≤30%的同时CHOL≤2.0mmol/L,病死率高。CHOL与PTA间存在正相关(r=0.369)。【结论】CHOL可作为妊娠合并重型肝炎预后判断的临床联合指标之一,CHOL≤1.6mmol/L、CHOL进行性下降、PTA≤30%的同时CHOL≤2.0mmol/L,均提示预后不良。

[Objective] To investigate the clinical significance of serum cholesterol in predicting the prognosis of pregnancy complicating hepatitis gravis. [Methods] Clinical data of 40 patients with pregnancy complicating hepatitis gravis for hospitalization were collected, difference of CHOL between survival group and dead group and the relationship between CHOL and the change of patient＇s condition and prognosis were analyzed retrospectively. [Results] The difference of CHOL between survival group and dead group in pregnancy complicating hepatitis gravis was significant. CHOL ≤ 1.6 mmol/L, progressive descending of CHOL, and PTA ≤ 30% complicating with CHOL ≤ 2.0 mmol/L, all mean high fatality. There was positive correlation between CHOL and PTA （r = 0.369）. [Conclusions] The descending of CHOL can be one of the clinical combined indexes of judging prognosis for pregnancy complicating hepatitis gravis, CHOL ≤ 1.6 mmol/L, progressive descending of CHOL and PTA ≤ 30% complicating with CHOL ≤ 2.0 mmol/L, all predict poor prognosis.