PD98059对人卵巢癌细胞株HO-8910增殖的作用
摘要
卵巢癌是妇科肿瘤致死率最高的恶性肿瘤之一，预后很差，5年生存率不超过35％。近年来，卵巢癌的发病率有逐年上升趋势，却无有效的治疗方法。因此，研究卵巢癌的分子发病机制，寻找有效的卵巢癌的早期诊断和有效治疗的手段成为近期研究热点。Wang等发现，与正常卵巢组织及良性卵巢病变相比，卵巢癌细胞中细胞外调节蛋白激酶1／2（ERK1／2）蛋白明显升高，表明ERK1／2信号通路与卵巢癌的发生发展密切相关。
出处
《中华病理学杂志》
CAS
CSCD
北大核心
2008年第9期625-626,共2页
Chinese Journal of Pathology
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