磷灰石/硅灰石生物玻璃基骨水泥的溶胶-凝胶法制备及性能

PREPARATION AND PROPERTIES OF SOL-GEL-DERIVED APATITE/WOLLASTONITE BIOGLASS BASED BONE CEMENT

为了获得高性能的玻璃基骨水泥,采用溶胶–凝胶法制备了磷灰石/硅灰石(apatite/wollastonite,AW)生物玻璃,将其作为固相粉末与柠檬酸固化液均匀混合制得了AW玻璃基骨水泥(glass-based bone cement,GBC),探讨了溶胶–凝胶法制备的AW生物玻璃作为GBC固相粉末的可能性。用X射线衍射、红外光谱和强度测试仪对不同温度热处理的AW生物玻璃粉末的晶相转变以及骨水泥在人体模拟体液中浸泡不同时间后的晶相组成和抗压强度进行了研究。结果表明:AW生物玻璃粉末经700℃热处理后形成了硅灰石和羟基磷灰石晶相,且温度越高晶相越完整;以900℃热处理后的AW生物玻璃粉末作为固相所制备的GBC随着浸泡时间的增加,骨水泥固化体中生成了更多量的CaCO3晶体及少量的羟基磷灰石晶体,且此种GBC的抗压强度最大。

In order to obtain glass bone cement with high properties, apatite/wollastonite （AW） bioglass was prepared by a sol-gel method, and AW glass-based bone cement （GBC） was synthesized by mixing this bioglass powder with a citric acid liquid. The possibility of using apatite/wollastonite bioglass as the solid body powder of glass bone cement was investigated. The phase transformation of AW bioglass heat treated at different temperatures, as well as the phase composition and compressive strength of GBC samples immersed in simulated body fluid for different times were analyzed by X-ray diffraction （XRD）, Fourier transform infrared spectroscopy （FTIR） and omnipotent electronic intensity measurement. The results indicate that apatite and wollastonite crystals are formed at 700℃ and the crystallization of AW glass ceramic become stronger with the increasing of heat treatment temperature. For the GBC samples of 900℃ heat-treated AW glass ceramic, with the prolonging of the immersion time in simulated body fluid, more CaCO3 and a few hydroxyapatite crystals are formed, and the compressive strength of this GBC sample is the strongest.