氟尿嘧啶柱撑镁铝层状复合氢氧化物的结构与性能表征

Structure and property characterization of MgAl type layered double hydroxides intercalated with antineoplastic drug fluorouracil

MgAl type layered double hydroxide(LDH) obtained by co-precipitation,has been used as precursors to intercalate an antineoplastic agent fluorouracil to prepare an intercalation compound LDH-FLU with ion exchange reaction.The transformation in structure and crystalline state property from LDH to LDH-FLU has been investigated via XRD,FT-IR,TEM,TG-DSC,and BET-N2 surface area characterizations.The results show that the structure of the intercalation compound is homologous to a monolayer parallel pillar-layer interaction model.Compared with LDH,the crystallinity of this compound is enhanced,the proportion of the inter-lamellar constitution H2O is increased,the thermal decomposition of intermediate crystalline phase complicated,the stack order of grains intensified in c axial,the absorbability of micro-pore decreased,and the pore volume of inter-laminar are reduced evidently.

MgAl type layered double hydroxide （LDH） obtained by co -precipitation, has been used as precursors to intercalate an antineoplastie agent fluorouraeil to prepare an intercalation compound LDH - FLU with ion exchange reaction. The transformation in structure and crystalline state property from LDH to LDH- FLU has been investigated via XRD, FT- IR, TEM, TG -DSC, and BET- N2 surface area characterizations. The results show that the structure of the intercalation compound is homologous to a monolayer parallel pillar - layer interaction model. Compared with LDH, the erystallinity of this compound is enhanced, the proportion of the inter - lamellar constitution H2O is increased, the thermal decomposition of intermediate crystalline phase complicated, the stack order of grains intensified in c axial, the absorbability of micro - pore decreased, and the pore volune of inter - laminar are reduced evidently.