微波辅助下5-氟尿嘧啶-1-基乙酸的绿色合成

Green Synthesis of 5-Fluorouracil-1-yl Acetic Acid Under Microwave Irradiation

在微波辐射下,以水作溶剂,以氯乙酸、5-氟尿嘧啶为原料合成了具有重要生理活性的标题化合物5-氟尿嘧啶1-基乙酸.产率86.8%.该方法反应时间短,分离方便,产品纯度高.

The bioactive title compound, 5-fluorouracil-1-yl acetic acid was synthesized from 5-fluorouracil and chloroacetic acid with high purity, using water as solvent under microwave irradiation. The yield was up to 86.8 %.