高血压脑出血患者血清IL-18水平变化与Th1/Th2失衡的关系及意义

The relationship between the levels of IL-18 and the balance of helper T cell in patients with hypertensive cerebral hemorrhage

目的:探讨高血压脑出血患者血清IL-18水平变化与Th1/Th2失衡的关系及意义。方法:确诊的36例高血压脑出血患者作为病例组,41例排除脑出血的高血压病患者作为对照组。采用ELISA法检测血浆中IL-18、IFN-γ和IL-4水平。结果:病例组IL-18、IFN-γ水平增高,与对照组相比差异有统计学意义;病例组IL-4水平变化小,两组间IL-4差异无统计学意义;病例组IFN-γ与IL-4比值较对照组增大;IL-18水平与IFN-γ水平呈正相关,而与IL-4水平无相关性。结论:高血压脑出血患者血清IL-18增高促进了辅助性T淋巴细胞亚群平衡偏移,主要表现为Th1细胞活性升高,可能是其发病机制之一。

Objective：To evaluate the relationship between the levels of IL-18 and the balance of helper T cell in patients with hypertensive cerebral hemorrhage. Method： Seventy-seven hypertensive patients were divided into two groups ： group one consisting of 36 cases with cerebral hemorrhage （case group） and the control one consisting of 41 cases without cerebral hemorrhage. The levels of plasma IL-18, IFN-γ and IL-4 were measured using ELISA. Result： IL-18 and IFN-γ levels were found to be sharply increased in case group compared with the control group. The levels of IL-4 were no difference. The ratios of IFN-γ/IL-4 in case group were higher than those in controls. IL-18 were positively correlated with the levels of IFN-γ（ r =0.58 ,P 〈0.01 ）and no correlation was found between IL-18 and IL-4 （ r = 0.08, P 〉 0.05 ）. Conclusion： High levels of IL-18 may associate with the imbalance of Th1/Th2subsets, which may involve in cerebral hemorrhage progression in hypertensive patients.