盐酸戊乙奎醚注射液用于手外科麻醉前用药的临床观察

Clinical observation of the effects of penehyclidine hydrochloride as premedication in hand surgery

目的:观察静脉注射盐酸戊乙奎醚注射液作为手外科麻醉前用药对心率、血压及口干程度的影响。方法:40例ASAⅠ-Ⅱ臂丛阻滞下行手外科手术患者,随机分为两组:Ⅰ组(盐酸戊乙奎醚组)和Ⅱ组(硫酸阿托品组),每组20例,术前静脉注射盐酸戊乙奎醚注射液、硫酸阿托品注射液,观察给药前、给药后1、5、10、30、50m in心率、血压变化。给药后30m in用视觉模拟评分方法测定口干程度。结果:与Ⅱ组相比,Ⅰ组给药后1、5、10、30、50m in心率均降低(P<0.05);与给药前相比,Ⅱ组给药后1、5、10、30、50m in心率均升高(P<0.05)。给药前、给药后1、5、10、30、50m in两组血压变化无显著差异(P>0.05)。与给药前相比,给药后两组视觉模拟口干评分均明显增加(P<0.05),两组间无显著差异(P>0.05)。结论:盐酸戊乙奎醚注射液对心率、血压无明显影响,对腺体分泌抑制明显,无明显不良反应,可安全用于手外科麻醉前用药。

Objective：To observe the effect of penehyclidine hydrochloride as premedication in hand surgery. Methods：40 patients receiving brachial plexus block undergoing hand surgery were randomly allocated into 2 groups： receive penehyclidine hydrochloride, atropine for injection intravenous respectively as premedication. Heart rate, blood pressure were measured before the injection and also 1, 5, 10, 30 and 50 minutes after it. VAS of thirst were examined 30 minutes after injection. Results：The heart rate significantly decreased in penehyelidine hydrochloride groups and increased in atropine groups. （P 〈0.05） Compared with baseline, BP had no significant difference at every point. （ P 〉 0. 05） VAS of thirst significantly increased in penehyelidine hydrocb_lofide groups and atropine groups （P 〈 0.05）, there is no difference between the two groups （P 〉 0.05 ）. Conclusion： Penehyclidine hydrochloride not only has less influence on heart rate and blood pressure, but decrease the secretion of salivary gland. The effect of Penehyelidine hydrochlofide used as premeditation in hand surgery is definite and safe.