摘要
2-氯乙醇经氯甲基化、与乙醇钠反应制得1-氯-2-(乙酰氧基甲氧基)乙烷,与2,9-二乙酰鸟嘌呤经缩合、脱乙酰化得到9-(2-氯乙氧基甲基)鸟嘌呤,再与N-[(1-乙氧羰基)烯丙-2-基]-L-缬氨酸钠反应后水解得到伐昔洛韦,总收率约18.4% (按2,9-二乙酰鸟嘌呤计)。
Valacyclovir was synthesized from 2-chloroethanol by chloromethylation and reaction with CH3ONa to give 1-chloro-2- （acetoxymethoxy） ethane, which was subjected to condensation with 2,9-diacetyl guanine, deacetylation, reaction with sodium N- [ （1-ethoxycarbonyl） -2-allyl] -L-valine and then hydrolysis with an overall yield of about 18.4 % （based on 2,9-diacetyl guanine）.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2008年第9期643-645,共3页
Chinese Journal of Pharmaceuticals
关键词
伐昔洛韦
抗病毒药
合成
valacyclovir
antivirtus
synthesis
