摘要
目的制备R-(+)-硫代四氢呋喃-2-甲酸。方法以四氢呋喃-2-甲酸为原料,经拆分、氯代、取代3步反应得到R-(+)-硫代四氢呋喃-2-甲酸。结果反应总收率为29%,产物结构经1H-NMR和MS确证。结论通过实验摸索了一条制备光学纯度的R-(+)-硫代四氢呋喃-2-甲酸的路线,该方法简单、易于操作。
Objective To prepare R-(+)-thiotetrahydrofunan-2-carboxylic acid. Method R-(+)- thiotetrahydrofuran-2-carboxylic acid was synthesized from tetrahydrofuran-2-carboxylic acid via three steps: resolution, chlorination and displacement. Results The total yield was 29% and the structure of desired compound was confirmed by 1H-NMR and MS. Conclusions The new route for synthesis of R-(+)-thiotetrahydrofuran-2-carboxylic acid is developed, and the process is easy to operate.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2008年第9期714-715,共2页
Journal of Shenyang Pharmaceutical University