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高通量药物代谢与毒性筛选平台研究进展 被引量:1

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出处 《中南药学》 CAS 2008年第5期596-599,共4页 Central South Pharmacy
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同被引文献85

  • 1郭宾,段俊敏,王美玲,王晓莹,陈波.流动注射-串联质谱法快速筛选植物提取物对药物代谢酶的抑制潜性[J].分析化学,2010,38(12):11692-1697. 被引量:5
  • 2王青秀,吴纯启,廖明阳.细胞色素P450酶诱导和抑制效应高通量筛选系统研究进展[J].中国新药杂志,2007,16(3):204-208. 被引量:7
  • 3STEPHEN G S. Glimpsing the critical intermediate in cytochrome P450 oxidations [J]. Science, 2010, 330 (6006) : 924-925.
  • 4DENISOV I G, MAKRIS T M, SLIGAR S G, et al. Structure and chemistry of cytochrome P450 [J]. Chem Rev, 2005, 105(6).. 2253--2278.
  • 5GUENGERICH F P. Common and uncommon eyto- chrome P450 reactions related to metabolism and chemi- cal toxicity [J]. Chem Res Toxicol, 2001, 14(6): 611 --650.
  • 6ZANGAR R C, DAVYDOV D R, VERMA S. Mecha- nisms that regulate production of reactive oxygen spe- cies by cytochrome P450 [J]. Toxicol Appl Pharm, 2004, 199(3): 316--331.
  • 7RENDIC S, GUENGERICH F P. Survey of human oxi-doreductases and cytoehrome P450 enzymes involved in the metabolism of xenobiotic and natural chemicals [J]. Chem Res Tox, 2014, 28(1): 38--42.
  • 8LIEBLER D C, GUENGERICH F P. Elucidating mech- anisms of drug-induced toxicity [J]. Nat Rev Drug Dis coy, 2005, 4(5).. 410--420.
  • 9PARK B K, BOOBIS A, CLARKE S, et al. Managing the challenge of chemically reactive metabolites in drug development [J]. Nat Rev Drug Discov, 2011, 10(4): 292--306.
  • 10HODGSON J. ADMET-turning chemicals into drugs [J]. Nature Bio, 2001, 19(8): 722--726.

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