摘要
目的探讨汉族健康人群5-羟色胺转运体基因(5-HTT LPR,5-HTT VNTR)、去甲肾上腺素转运体基因(NET T182C、NET G1287A单基因)及交互作用对人格的影响。方法严格按照入组标准筛取中国汉族健康人群367例,采用艾森克人格问卷(EPQ)测量人格的三个纬度,聚合酶链反应(PCR)检测5-HTT及NET基因多态性,使用SPSS13.0统计软件及多因子降维法(MDR)进行统计分析。结果①5-HTT VNTR各基因型及等位基因在人格维度间分布无差异(P〉0.05)。②神经质人格维度均数在5-HTT LPR各等位基因间分布有差异(t=2.232,P=0.026)。③内外向人格维度均数在NET T182C各等位基因间分布有差异(t=2.680,P=0.008)。④在内倾人格和外倾人格间,G1287A各基因型(χ^2=9.950,P=0.007)及等位基因(χ^2=9.644,P=0.002)分布差异有统计学意义,在其等位基因间,精神质人格维度均数分布有差异(t=3.226,P=0.001)。⑤未发现5-HTT LPR、5-HTT VNTR、NET T182C、NET G1287A间存在交互作用。结论①5-HTT VNTR可能与EPQ所测人格无关联。②5-HTT LPR与神经质人格相关,等位基因L是神经质人格的可疑危险因素。③NET T182C与内外向人格有关联,等位基因T是内倾人格的可疑危险因素。④NET G1287A与内外向、精神质人格相关,等位基因G是内倾人格的可疑危险因素;等位基因A是精神质人格的可疑危险因素。⑤尚未发现5-HTT、NET基因多态性间存在交互作用对人格产生影响。
Objective To assess the interaction to personality among 5-HTT LPR,5-HTT VNTR, NET T182C,NET G1287A. Methods 367 Han Chinese healthy people were assessed with EPQ personality include P,E,N latitude. Using PCR to detect gene polymorphism include 5-HTT and NET. Using SPSS13.0 and MDR to do statistical analysis. Results (1)The distribution variance of the 5-HTT VNTR genetype and allele don' t have statistical significauce among different personality latitude ( P 〉 0.05 ). (2)The mean T scores of N latitude' s have statistical significance among L/S allele( t = 2. 232, P= 0. 026). (3)The mean T scores of E latitude' s have statistical significance among T/C allele( t=2.680, P=0. 008). (4)The distribution variance of G1287A genetype( χ^2 = 9. 950, P = 0. 007 ) and allele ( χ^2 = 9. 644, P = 0. 002 ) have statistical significance between different grades in E latitude. The mean T scores of P latitude' s have statistical significance among G/A allele( t = 3. 226, P= 0. 001 ). (5)There were no interaction among 5-HTT LPR, 5-HTT VNTR, NET T182C, NET G1287A. Conclusions (1) There were no associations between the 5-HTT VNTR and EPQ personality latitude. (2)5-HTT LPR have associations with N latitude. L allele is the doubtful risk factor of neurotic personality. (3)NET T182C have associations with E latitude. T allele is the doubtful risk factor of introvert personality. (4)NET G1287A have associations with E and P latitude. G allele is the doubtful risk factor of introversion personality. A allele is the doubtful risk factor of psychoticism personality. (5)There were no interaction to personality among 5-HTT, NET genes polymorphisms.
出处
《中国行为医学科学》
CSCD
2008年第9期792-795,共4页
Chinese Journal of Behavioral Medical Science
基金
国家自然科学基金(30770770)
山西省科技攻关项目(2007031091-3)
山西省自然科学基金(2007011120)
山西省青年科学基金(2007021050)