中药脑康Ⅱ号对老年失眠患者生活质量和睡眠质量的影响

The clinical research of Naokang II in treating with aged insomnia patients

目的目的研究脑康Ⅱ号对老年失眠患者的生活质量和睡眠质量的影响。方法将206例老年失眠症患者随机分为分为安定治疗组、脑康Ⅱ号治疗组和安定＋脑康Ⅱ号治疗组，治疗4周。采用健康状况问卷（SF-36）量表评价患者生活质量、匹兹堡睡眠质量指数量表（PSQI）评价睡眠质量、治疗副反应量表评价相关副反应。结果安定组患者生理职能（RP）[（67．28±11．52）分]、精力（VT）[（62．27±9．03）分]、睡眠质量[（1．79±0．75）分]、入睡时间[（0．98±0．54）分]、睡眠时间[（1．21±0．69）分]、睡眠效率[（1．55±1．08）分]及总分[（8．68±1．32）分]较治疗前有显著改善（P〈0．05）。脑康Ⅱ号组患者VT[（66．50±7．03）分]、社会功能（SF）[（63．58±12．56）分]、情感职能（RE）[（85．43±10．51）分]、精神健康（MH）[（79．03±10．33）分]得分及PSQI除安眠药物外各方面得分均较治疗前有显著改善（P〈0．05）。中西医结合组患者RP、VT、SF、RE、MH得分及PSQI除安眠药物外各方面得分均较治疗前有显著改善（P〈0．05）。脑康Ⅱ号组在VT、SF、RE、NH、睡眠质量、睡眠效率、睡眠紊乱、日间功能及总分方面显著优于安定组。中西医结合组在RP、VT、SF、RE、MH、睡眠质量、睡眠效率、睡眠紊乱、日间功能及总分方面显著优于安定组，并在RP、VT、SF、入睡时间方面显著优于脑康Ⅱ组。结论中药脑康Ⅱ号在改善老年失眠患者的整体生活质量和睡眠质量方面具有较好的疗效。

Objective To research the therapeutic effect of Naokang Ⅱ in treating with aged insomnia pa tients. Methods 206 aged insomnia patients were divided into three groups. The first group was treated with diazepam, the second group was treated with Naokang Ⅱ, and the third group was treated with both diazepam and Naokang Ⅱ. Patients in all three groups were treated for 4 weeks. And SF-36, PSQI and TESS was used to evaluate their quality of life, sleeping quality and side effect respectively. Results Diazepam could significantly improve patients＇ RP（ 67.28 ± 11.52 ）, VT（ 62.27 ± 9.03 ）, sleeping quality （ 1.79 ± 0.75 ）, sleeping time （ 0.98 ± 0.54）, sleeping effective （ 1.55 ± 1.08 ） and total score （ 8.68 ± 1.32 ）. Naokang Ⅱ could significantly improve patients＇ VT（66.50 ± 7.03 ）, SF（ 63.58 ± 12.56 ）, RE （ 85.43 ± 10.51 ）, MH （ 79.03 ± 10.33 ）, PSQI score, except hypnotic. Diazepam combined with Naokang Ⅱ could significantly improve patients＇ RP,VT, SF, RE, MH, and PSQ1 score, except hypnotic. Compared with diazepam, Naokang Ⅱ could significantly improve patients＇ VT, SF, RE, MH, sleeping quality,sleeping effective, sleeping turbulence, day function and total score, except fall sleeping time of the first week. Compared with diazepam, diazepam combined with Naokang Ⅱ could significantly improve patients＇ RP, VT, SF, RE, MH, sleeping quality, sleeping effective, sleeping turbulence, day function and total score. Compared with Naokang Ⅱ, diazepam combined with Naokang Ⅱ could significantly improve patients＇ RP, VT, SF, fall sleeping time. Conclusion Chinese medicine gave much attention to aged insomnia pa- tients＇ special physiological character, and Chinese medicine could adjust the balance of persons＇ yin and yang, based on their total body. So, Chinese medicine had a better clinical effective in improving aged insomnia patients＇ quality of life and sleeping quality.