n-3不饱和脂肪酸辅助治疗抑郁自杀未遂者的临床疗效

Observasion supplementary effect of omega-3 polyunsaturated fatty acids to medication treatment for depressive disorder of suicide attempters

目的探讨n-3不饱和脂肪酸（PUFA）对改善抑郁的作用。方法39例自杀未遂的抑郁症患者在接受标准抗抑郁药物治疗过程中服用PUFA及安慰剂3个月，应用汉密尔顿抑郁量表及贝克抑郁自评问卷在干预前，干预1．5个月及干预3个月时进行评估。结果1．干预前和干预后n-3PUFA组和安慰剂组之间汉密顿抑郁量表（HRSD）得分[（23．52±6．92）分，（21．56±8．71）分；（14．62±9．28）分，（12．00±8．54）分]上的均差异无显著性（P〉0．05）；干预前和干预后n-3PUFA组和安慰剂组之间BDI的得分上的均差异无显著性（P〉0．05）。2．2组红细胞膜中二十碳五烯酸水平，二十二碳六烯酸水平及n-6／n-3水平干预1．5个月和干预3个月时均差异具有显著性（P〈0．05）。结论n-3不饱和脂肪酸无辅助治疗抑郁症的作用。

Objective To determine the effect of adding n-3 polyunsaturated fatty acids in attempted suicides who were depression. Methods A randomized double-blind placebo-controlled 3 months trial comparing n- 3 polyunsaturated fatty acids versus placebo was conducted on 39 attempted suicides who were depression. Mood was assessed at baseline and then 1.5 and 3 months using the Hamilton Rating Scale for Depression（HRSD） and the Beck Depression Inventory（BDI）. Results 1. There were no significant differences between n-3 PUFA intervention group and control group on scores of HRSD at baseline and after 3 months intervention （23.52 ± 6.92, 21.56 ± 8.71 ; 14.62 ± 9.28,12, 00 ± 8.54 ） （ P 〉 0.05 ）. There were no signifieant differences between n-3 PUFA intervention group and control group on scores of BDI at baseline and after 3 months intervention（ P 〉 0.05 ）. 2. There were significant differences between n-3 PUFA intervention group and control group on EPA, DHA and n-6/ n-3 at 2 points of time （P 〈 0.05 ）. Conclusion n-3 polyunsaturated fatty acids were not effective as an add-on therapy for depression.