糖尿病肾病合并顽固性高血压降压治疗方法的研究

Study on the methodology of treatment of diabetic patients complicated with refratory hypetension

目的探索糖尿病肾病合并顽固性高血压联合降压的优化方案。方法对36例糖尿病肾病合并顽固性高血压患者随机分为治疗组和对照组,观察两组治疗前后降压情况、副作用和实验证据变化。结果治疗组以卡托普利联合苯磺酸氨氯地平和螺内酯治疗4周,SBP和DBP以治疗前的162.0±15.2和92.1±8.6下降至128.8±6.8和81.2±5.9,略优于以倍他洛克联合苯磺酸氨氯地平和氢氯噻嗪的对照组,而且副作用少,耐受性好。结论卡托普利联合苯磺酸氨氯地平和螺内酯治疗高血压病既可减少药量,减少副作用,又可增加降压效应,值得进一步推广。

Objective To investigate the perfected antihypertensive treatment of diabetic nephropathy complicated with refractory hypertension. Methods There 36 diabetic nephropathy patients complicated with refractory hypertension were treated with two different therapies and the results were observed before and after the treatment. Results Effects of captopril combined with amlodipine and spironolactonum was superior to betaloc in combination with amlodipine and hydrochlorothiazide in addition to a light side effects and well tolerated. Conclusion Captopril combined with amlodipine and spironolactonum is effective for reatment of hypertension can reduce the quatity of drugs and side effects, worthy to be used for clinical treatment.