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肾小球系膜细胞蛋白激酶C同工酶的激活与糖尿病肾病

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摘要 糖尿病肾病（DN）是糖尿病全身微血管并发症之一，以早期肾小球滤过率升高、继以肾小球毛细血管基底膜增厚、系膜区基质沉积，最终弥漫性或结节性肾小球硬化形成为特征。高血糖是DN损害的主要因素，而在高糖环境下肾小球系膜细胞（mesangial cell，MC）蛋白激酶c（PKC）的激活是进展性DN的中心环节。
作者 胡民坚(综述) 刘华锋(审校)
机构地区 广东医学院附属医院肾病研究所 不详
出处 《国际泌尿系统杂志》 2008年第5期692-695,共4页 International Journal of Urology and Nephrology
关键词 糖尿病肾病 肾小球 蛋白激酶C
分类号 R692.39 [医药卫生—泌尿科学]
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参考文献23

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二级参考文献25

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  • 2任路平,张海燕,刘国良.血浆血管内皮生长因子水平与糖尿病肾病的相关性及血管紧张素受体拮抗剂的干预作用[J].中华糖尿病杂志（1006-6187）,2005,13(3):228-229. 被引量：3
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国际泌尿系统杂志
2008年 第5期

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