三维适形放疗技术治疗晚期非小细胞肺癌的临床研究

3DCRT in the treatment of NSCLC

目的:研究局部晚期NSCLC应用三维适形放疗技术(3DCRT)治疗的放疗方式、生存率及并发症。方法:收集65例行三维适形放疗治疗的局部晚期NSCLC患者的临床资料进行分析。结果:运用3DCRT技术,患者照射剂量可以安全地提高到83.8Gy。90.3Gy为最大剂量,产生的放射毒性太大,有2例放射相关死亡,此剂量不能耐受。没有预防照射者选择性淋巴结转移率低于10%,这表明选择性淋巴结的预防性照射不是必需的。结论:3DCRT能改善肿瘤的局部控制率,提高患者的生存率。同时将放疗的剂量控制在接受范围内。

Objective To study the radiotherpy way, survival rate and complication of three dimensional suitable shape radiotherapy （3DCRT） in the treatment of later period NSCLC. Method Data of 65 patients with later period NSCLC treated with 3DCRT were analyzed. Results The exposure dose can up to 83.8Gy. The most exposure dose was 90.3Gy, with large toxicity, and led to 2 eases of emission correlation death. The selective lymph node transfer rate in patients without prevention radiotherapy was lower than 10%, and indicated that the prevention radiotherapy on seletive lymph node was not necessary. Conclusion 3DCRT can improve the tumor local control rate, elevate the survival rate, and the radio dose is in the received extent.