超细化复方化毒膏治疗急性肿疡的临床疗效及抗炎研究

Anti-inflammatory Effects of Ultramicro Compound Huadu Paste in Treatment of Acute Oncotic Ulcer

目的:观察超细粉化的复方化毒膏治疗急性肿疡的临床疗效,并通过动物实验探讨作用机理。方法:130例外科门诊及住院的急性肿疡患者随机分为治疗组50例、对照1组50例、对照2组30例,分别外用超细化复方化毒膏、传统复方化毒膏、达维帮软膏,治疗前后进行症状体征评分判定;实验应用大鼠足爪肿胀法造急性炎症模型,分组观察血流灌注量、血细胞浓度、血流速度、体表温度、足爪肿胀等指标。结果:痊愈率:治疗组76%,对照1组48%,对照2组33%;总有效率:治疗组96%,对照1组94%,对照2组67%。结论:超细化复方化毒膏是治疗急性肿疡的有效中医外用制剂,比传统复方化毒膏有更明显的抗炎作用。

Objective：To observe the clinical effectiveness of Ultramicro Compound Huadu Paste on acute oncotic ulcer （AOC）, and in- vestigate action mechanism by animal tests. Methods：One hundred and thirty in-and outgoing AOC patients were randomly grouped to the treatment group, control A group, control B group to be treated with the ultramicro paste, the traditional paste, Ciprofloxacin respectively, and rated on symptoms and physical signs. Rat model was established using paw-swelling tests and observed on blood perfusion, concentration of blood cells, velocity of blood flow, skin temperature, swelling of paws. Results： The cure rate and total effective rate for treatment group were 76% and 96%, 48% and 94% for the control A group, 33% and 67% for the control B group. Conclusion：The external preparation of Chinese medicine -Ultramicro Compound Huadu Paste has more significant anti-inflammatory effect than the traditional Paste in treatment of acute oncotic ulcer.