人工肝治疗药物性肝衰竭疗效观察

Curative Effect Observation of Artificial Liver Support System in Treating Patients with Drug-induced Hepatic Failure

目的探讨人工肝支持系统(ALSS)治疗药物性肝衰竭临床疗效。方法24例药物性肝功能衰竭患者在综合护肝治疗基础上给予ALSS(包括血浆置换、血液灌流)治疗,观察患者临床症状,肝功能、血氨、凝血酶原活动度的变化。结果ALSS治疗后,患者临床症状均得到不同程度的改善;血浆总胆红素、直接胆红素、丙氨酸转氨酶、天门冬氨酸转氨酶、血氨较治疗前明显降低(P<0.01或P<0.05),PTa上升(P<0.05);有效率(治愈或好转)为79.2%。不良反应较轻。结论ALSS治疗药物性肝衰竭安全、有效。

Objective To discuss the clinical curative effect of artificial liver support system （ALSS） in treating patients with druginduced hepatic failure （dHF）. Methods 24 cases with dHF, besides haptotherapy, received ALSS, including plasma exchange and hemoperfusion; an observation was made to the clinical symptoms and the changes of hepatic function, blood ammonia and prothrombin activities. Results The clinical symptoms were improved at certain degrees; the total bilirubin, direct bilirubin, alanine tranasaminase （ALT）, aspartate tranasaminase （AST） and blood ammonia were much lower than those before treatment （ P 〈 0.05 or P 〈 0.01） while PTa increased （ P 〈 0.05 ） ; the effective rate was 79..2 %, and side - effects were mild. Conclusions ALSS is safe and effective intreating patients with dHP.